Job Description
Job Description
Job Title: Proteomics Bench Scientist
Location: Andover MA 01810
Duration: 12 months
POSITION SUMMARY
- Candidate will be responsible for developing proteomics workflows using advanced high-resolution mass spectrometry techniques.
- Key duties include development and optimization of sample preparation methods from cell lines and other matrices for mass spectrometry analysis and data processing with various bioinformatics tools; collaborative work with colleagues; accurately documenting all activities in an electronic lab notebook (ELN).
- This role requires expertise in LC-MS based proteomics.
- Experience with cell culture and cell manipulation is a plus.
POSITION RESPONSIBILITIES
• Applying knowledge of proteomics workflows to develop and implement optimal strategies for the preparation and analysis of cellular samples
• Working collaboratively with experts in the team to advance innovative proteomics strategies
• Employing different bioinformatics tools for data analysis and fitting
• Consistent record keeping using an electronic lab notebook (ELN)
ORGANIZATIONAL RELATIONSHIPS
• This hire will interact daily with the managers and 3-4 colleagues in the cross-functional team for method development, laboratory work prioritization, experiment planning and execution.
The hire might also work on common assignments with colleagues in a larger bioanalytical group at the same location, as needed.
The hire will participate in bi-weekly group meetings and other team meetings and discussions, as relevant to their work.
EDUCATION AND EXPERIENCE
• M.Sc 5+ years, PhD 0+ years in a relevant scientific field with a documented experience in proteomics and mass-spectrometry
TECHNICAL SKILLS REQUIREMENTS
Required:
• Advanced knowledge and documented expertise with mass-spectrometry based proteomics approaches: label- or label-free quantification (TMT or DIA)
• Experience with high-resolution mass-spectrometry instruments, such as Orbitraps and timsTOF
• Experience with sample preparation based on enrichment (incl. affinity purification), and universal protein extraction
• Bioinformatics skills relevant for mass-spec data search, statistical analysis and visualization
Preferable:
• Experience with membrane protein analysis and/or cell surface proteomics
• Knowledge of cell culture techniques and experience conducitng cell-based assays
PHYSICAL POSITION REQUIREMENTS
• Walking, taking the stairs, standing, sitting as appropriate for a laboratory-based position