Job Description
Job Description
Title: Analytical Chemist
Hiring Organization: Connexion Systems & Engineering
Compensation, Benefits, and Employment Type
- Duration: 1+ year contract
- Pay rate: $55 - $70/hr (W2)
- Job Location: Boston, MA (Hybrid – 3 days onsite)
- Schedule: M-F, 1st shift
- Job#: bh18555
Description:
We are seeking an experienced Analytical Chemist to support late-stage development activities within a Technical Operations Analytical team. This role will focus on providing analytical support for oligonucleotides, peptides, and peptide-oligonucleotide conjugates, with a strong emphasis on method development, transfer, and validation in a GMP environment.
Key Responsibilities
- Provide analytical support for oligonucleotide and peptide-oligonucleotide conjugated compounds in late-stage development
- Independently lead analytical method development, transfer, and validation activities
- Develop and optimize robust analytical methods including LC/MS, IP-RP HPLC, and SAX HPLC for highly modified oligonucleotide drug substances
- Perform analysis and purification using techniques such as UPLC, LC-MS, and LC-MS/MS
- Operate, maintain, and troubleshoot analytical instrumentation
- Ensure compliance with GLP/GMP standards and documentation requirements
- Author technical reports, protocols, and validation documentation
- Collaborate effectively with cross-functional teams while working independently as an analytical subject-matter expert
Qualifications
- BS or MS in Chemistry or a related scientific discipline
- 5+ years of commercial, GMP analytical laboratory experience
- Hands-on experience with oligonucleotide therapeutics is required
- Strong background in analytical method development and validation
- Proficiency with mass spectrometry and purification techniques
- Experience with RP-HPLC, SAX-HPLC, UPLC, and LC-MS
- Familiarity with instrumentation from Agilent, Waters, and/or Thermo and associated software
- Excellent written and verbal communication skills
- Proven ability to work independently and as part of a collaborative team