Sr. Scientist / Associate Director Immunology and Inflammation
Job Description
Monte Rosa Therapeutics is looking for an energetic and self-motivated Discovery Immunologist who will join our Boston based, Immunology & inflammation discovery biology team . Will be responsible for leveraging our novel platform to develop first-in-class medicines and new chemical modalities This role includes both strategic scientific thinking & hands on bench-work. The candidate will make critical contributions to target identification & validation, progression & translational application of molecular glue degraders for immunology-related targets. The ideal candidate brings expertise in immunology, development of assays to test immune cell functions, translational application and a background in industrial small molecule drug discovery.
Principal Duties and Responsibilities
- Review potential targets identified by our platform for therapeutic potential in non-oncology -related diseases with emphasis on autoinflammatory/immunology diseases
- Devise & implement biology strategy to drive target progression towards strategic milestones (biology program leadership)
- Develop relevant assays to determine downstream effects of target degradation (e.g. signaling, viability, cytokine secretion, function) & link phenotypes with disease biology
- Interpret, present and report research findings at internal meetings and external scientific conferences in relevant context
- Work collaboratively in a cross-functional team (e.g. chemistry, proteomics, data science, discovery sciences, animal care facility)
Qualifications
- PhD or Postdoc equivalent in Immunology with 5+ years hands-on experience in drug discovery research in an industrial setting
- Project lead experience and/or driving preclinical immunology-related targets towards milestones
- Strong understanding of key drivers of autoimmune and inflammatory diseases & passion for science and innovation
- Proficient in immune cell isolation and multi-parameter flow cytometry
- Extensive technical expertise in primary immune cell functional assay development
- Experience with a variety of molecular & cell biology methods and assays such as western blotting, JESS/WES, ELISA, qRT-PCR, CRISPr/shRNA, cytokine secretion, transcriptomics
- Ability to implement and/or oversee in vivo and ex vivo murine studies
- Experience with external CROs to support project progression and meet deadlines
- Demonstrated ability to work in a dynamic, action-oriented, cross-functional team environment
- Experience managing and mentoring direct reports
- Excellent communication skills and ability to articulate scientific results and implications in a concise and context-dependent manner
- Excellent organizational & time management skills with flexibility to accommodate rapidly changing priorities and deadlines
- Protein degradation experience is a plus
Interested candidates should forward CV and cover letter to careers-us@monterosatx.com or apply on line www.monterosatx.com
About Monte Rosa
Monte Rosa Therapeutics is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs, which spans oncology, autoimmune and inflammatory disease and beyond, and has a strategic collaboration with Roche to discover and develop MGDs against targets in cancer and neurological diseases previously considered impossible to drug. For more information, visit www.monterosatx.com