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city

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<h3>Job Description</h3>
Job Descriptionjob summary: 
<ul>
<li>To perform experiments, organize data and analyze results under minimal supervision. With minimal supervision, plans, conducts or monitors experiments, records and organizes data, analyses results, generates robust and reliable data and/or ensures that contracted studies are conducted in compliance with the respective protocol and applicable guidelines and regulations.</li>
</ul>
 location: Cambridge, Massachusetts job type: Contract salary: $29.00 - 33.44 per hour work hours: 9 to 5 education: Bachelors responsibilities: 
<ul>
<li>Monitors or follows established experimental design and protocols and performs routine tasks and studies to obtain reproducible and reliable results with limited supervision,</li>
<li>Plans, monitors or conducts, analyzes and records experiments, and provides interpretation of data,</li>
<li>Effectively transfers experimental methods from literature to the lab and makes modifications as necessary,</li>
<li>Develops and implements new protocols with moderate review,</li>
<li>Works efficiently in a matrix team environment and collaborates with coworkers,</li>
<li>Communicates data and interpretation to work group,</li>
<li>Skilled at developing systems to ensure quality data,</li>
<li>Skilled and/or knowledgeable in the use of standard laboratory equipment and with one or more major laboratory instruments/techniques (HPLC, CE, physical property testing...),</li>
<li>Effectively trouble-shoots equipment and experimental difficulties,</li>
<li>Contributes to internal/external reports, papers, presentations, regulatory documents, invention disclosure submissions and/or patents,</li>
<li>Participates in department-wide support efforts such as safety, recruiting and committees, May train staff and/or supervise others,</li>
<li>Coordinates and organizes resources needed to complete the task,</li>
<li>Understands when to seek input and when to make independent judgments.</li>
</ul>
 qualifications: 
<ul>
<li>Minimum BS degree (MS is preferred) in Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, Biology or related discipline and at least 2 year experience in a Biopharmaceutical working environment.</li>
</ul>
#LI-HK1
 skills: Chemistry, High Pressure Liquid Chromatography (HPLC) 
 Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status. At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact <a href="mailto:HRsupport@randstadusa.com" target="_blank">HRsupport@randstadusa.com</a>. Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&amp;D, and life insurance offerings, short-term disability, and a 401K plan (all benefits are based on eligibility). This posting is open for thirty (30) days. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Associate Scientist

<h3>Job Description</h3>
Job Description
Are you ready to join a team that's pioneering the future of medicine? We are seeking a highly motivated and skilled Quality Control (QC) Analyst to focus on Environmental Monitoring (EM) within our state-of-the-art Good Manufacturing Practice (GMP) laboratories.
In this critical role, you'll be responsible for executing the routine and specialized sampling necessary to ensure the highest standards of environmental control for our groundbreaking technology. If you thrive in a fast-paced, collaborative environment and have a passion for microbiological quality assurance, this is your opportunity to make a direct impact on transforming human health.
salary: $40 - $42 per hour shift: First work hours: 8 AM - 4 PM education: Bachelors 
Responsibilities
What You'll Do: Core Responsibilities
<ul>
<li>Execute comprehensive Environmental Monitoring (EM) activities, including routine, in-process, and Environmental Monitoring Performance Qualification (EMPQ) sampling.</li>
<li>Perform essential utility sampling, including Water for Injection (WFI) and Compressed Gas sampling.</li>
<li>Maintain and calibrate laboratory equipment; perform general laboratory housekeeping and supply inventory.</li>
</ul>
What You'll Need: Required Qualifications
<ul>
<li>Education: A Bachelor's Degree in a Science, Technology, Engineering, or Math (STEM) discipline.</li>
<li>Experience: At least 3+ years of hands-on experience in a GMP Quality Control laboratory setting, with a strong focus on microbiology.</li>
</ul>
 Skills
<ul>
<li>Quality Control</li>
 Qualifications
<li>Years of experience: 0 years</li>
<li>Experience level: Experienced</li>
 Randstad is a world leader in matching great people with great companies. Our experienced agents will listen carefully to your employment needs and then work diligently to match your skills and qualifications to the right job and company. Whether you're looking for temporary, temporary-to-permanent or permanent opportunities, no one works harder for you than Randstad. 
 Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status. At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact <a href="mailto:HRsupport@randstadusa.com" target="_blank">HRsupport@randstadusa.com</a>. Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&amp;D, and life insurance offerings, short-term disability, and a 401K plan (all benefits are based on eligibility). This posting is open for thirty (30) days. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. 
</ul>

Lab Analyst

<h3>Job Description</h3>
Job Description
Quality Control Associate II (Microbiology | cGMP Lab)
 Location: Norwood, MA 02062 (Onsite – Not Remote) Schedule: Monday–Friday, 9:00 AM–5:00 PM Duration: 6-Month Contract | Target Dates: December 4, 2025 – June 5, 2026 Pay Rate: $50.00 per hour 
About the Role
We’re seeking an experienced and detail-oriented Quality Control Associate II to support cGMP QC microbiology testing and quality systems activities at our state-of-the-art manufacturing site in Norwood, MA.
In this role, you’ll perform routine QC testing for raw materials, drug substances, and finished products, while ensuring compliance with Good Manufacturing Practices (cGMP) and internal quality standards. You’ll work hands-on in a dynamic, fast-paced environment, collaborating with cross-functional teams to uphold quality and operational excellence.Why Join
<ul>
<li>
Opportunity to work in a cutting-edge biotech environment supporting life-changing therapeutics.
</li>
<li>
Exposure to advanced QC systems and global quality standards.
</li>
<li>
Be part of a passionate, mission-driven team committed to scientific excellence and patient impact.
</li>
</ul>
✅ Ready to take the next step in your quality control career?Apply now to join a world-class organization where your skills will directly contribute to improving global health.FOR MORE IMMEDIATE CONSIDERATION, email a current resume to <a href="mailto:iris.levy@randstadusa.com" target="_blank">iris.levy@randstadusa.com</a>
salary: $49 - $50 per hour shift: First work hours: 9 AM - 5 PM education: Bachelors 
Responsibilities
Key Responsibilities
<ul>
<li>
Perform QC microbiology testing, including bioburden, endotoxin, sterility, TOC, and microbial enumeration.
</li>
<li>
Maintain, calibrate, and troubleshoot laboratory equipment.
</li>
<li>
Manage QC laboratory supplies and inventory.
</li>
<li>
Author, review, and revise SOPs, protocols, and technical reports.
</li>
<li>
Participate in deviations, CAPAs, change controls, and non-conformance investigations.
</li>
<li>
Support audit readiness and continuous improvement initiatives.
</li>
<li>
Ensure strict adherence to cGMP documentation practices and regulatory requirements.
</li>
<li>
Maintain a clean, organized, and safe laboratory environment.
</li>
</ul>
Qualifications
Education: Bachelor’s degree in a STEM discipline (Biology, Microbiology, Chemistry, or related field). Experience: 2–3 years of hands-on experience in a cGMP laboratory, preferably in microbiology or biopharma QC.
Preferred Skills &amp; Competencies:
<ul>
<li>
Proficiency in Microsoft Office and electronic systems (LIMS, SAP, eQMS).
</li>
<li>
Strong understanding of GMP, aseptic technique, and laboratory instrumentation.
</li>
<li>
Knowledge of FDA, EU, and ICH regulatory guidelines.
</li>
<li>
Excellent troubleshooting, organization, and communication skills.
</li>
<li>
Ability to manage multiple projects in a fast-paced, collaborative environment.
</li>
</ul>
 Skills
<ul>
<li>cGMP (2 years of experience is required)</li>
<li>Microbiology (4 years of experience is required)</li>
<li>Quality Assurance</li>
<li>Quality Control</li>
<li>raw materials</li>
<li>laboratory (4 years of experience is required)</li>
 Qualifications
<li>Years of experience: 4 years</li>
<li>Experience level: Experienced</li>
 Randstad is a world leader in matching great people with great companies. Our experienced agents will listen carefully to your employment needs and then work diligently to match your skills and qualifications to the right job and company. Whether you're looking for temporary, temporary-to-permanent or permanent opportunities, no one works harder for you than Randstad. 
 Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status. At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact <a href="mailto:HRsupport@randstadusa.com" target="_blank">HRsupport@randstadusa.com</a>. Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including: medical, prescription, dental, vision, AD&amp;D, and life insurance offerings, short-term disability, and a 401K plan (all benefits are based on eligibility). This posting is open for thirty (30) days. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. 
</ul>

QC Associate II - Microbiology - cGMP Lab

<h3>Job Description</h3>
Job DescriptionThis is an Associate Scientist/Scientist role in the Bioanalytical Group to help developing, qualifying/validating bioanalytical methods, and analyzing small and large molecule in different biological matrix. Experienced in analytical techniques such as ELISA, MSD, PCR is preferred. Job title and compensation will be based on candidates credentials

Associate Scientist/Scientist

<h3>Job Description</h3>
Job Description
Senior Chemical Process Engineer Tewksbury, MA Direct Hire |
Summary
We are seeking a Senior Chemical Process Engineer with experience in process development, design, and construction of industrial facilities. This role will lead engineering efforts for complex process-facility projects, including new plant design, facility upgrades, and rehabilitation of high-hazard environments. The Senior Engineer will work closely with clients, vendors, contractors, and internal teams to deliver projects successfully.
Qualifications
<ul>
<li>B.S. in Chemical Engineering (minimum)</li>
<li>10+ years’ experience in chemical process engineering</li>
<li>Experience in process development, design, and construction</li>
<li>Ability to manage multiple projects and shifting priorities</li>
<li>Strong time management and leadership skills</li>
<li>Comfortable supervising junior engineers and collaborating with multidisciplinary teams</li>
<li>Background in chemical processing or related industries</li>
<li>Capital project management experience is a plus</li>
</ul>
Responsibilities
<ul>
<li>Lead and support engineering design for process-facility projects</li>
<li>Supervise and mentor engineering team members</li>
<li>Develop material &amp; energy balances and process flow diagrams (PFDs)</li>
<li>Prepare piping &amp; instrumentation diagrams (P&amp;IDs)</li>
<li>Size, specify, and procure equipment</li>
<li>Provide equipment and piping layout design support</li>
<li>Perform process and utility calculations</li>
<li>Support construction activities and process startups</li>
<li>Coordinate closely with vendors and clients to ensure requirements are met</li>
</ul>
Preferred Experience
<ul>
<li>Project management of capital projects</li>
<li>Construction support and startup/commissioning</li>
</ul>
Company DescriptionWhy Join · Collaborative, experienced engineering team. · Competitive salary &amp; full benefits. · Opportunity to deliver impactful next-generation products. 
<h3>Company Description</h3>
Why Join\r\n· Collaborative, experienced engineering team.\r\n· Competitive salary &amp; full benefits.\r\n· Opportunity to deliver impactful next-generation products.

Senior Chemical Process Engineer

<h3>Job Description</h3>
Job DescriptionCompany Description 
Canam Bridges designs, manufactures and installs steel bridges for major infrastructure contractors across North America. Canam Bridges is a member of Canam Group, which has over 5,100 employees and operates 22 plants in North America, as well as engineering offices in Canada, Romania, India and the Philippines.
Job Description 
Your life at Canam Bridges As a Metrologist at Canam Bridges, you will be responsible for taking factory measurements using “Station Total” and “Laser Tracker Faro” surveying tools. Your analytical mind will allow you to use your 3D vision superpowers to complete dimensional measurements. To break your routine, you will alternate between taking factory measurements, recording data, and writing reports. Your computer knowledge will make you an expert in AutoCAD and Polyworks. That said, it is your team that will give you the most satisfaction, because at Canam Bridges, we are a solid combination of expertise and pride!
Job Description Assist Plant Manager and production staff in developing production plans, ensure production objectives are met, offer recommendations, and implement production events and programs. The Metrologist is responsible for performing such work consistent with the company’s corporate mission, values, and departmental financial objectives.
Essential Functions
<ul>
<li>Assist in the production-planning process, schedules, assignments, and&nbsp;production sequences to meet production goals.</li>
<li>Read and analyze data, production schedules, and other records and reports to determine production productivity and to evaluate current production estimates and outputs.</li>
<li>Identify direct and indirect labor issues and production problems, make recommendations, and assist management in developing a corrective action plan.</li>
<li>Compile production planning notes, sketches, prints, schedules, contract documents and specifications into a formal build plan.</li>
<li>Aid in the detailing and manipulation of models to accommodate additional views for fabrication per planning session. Assist on designing fixtures and jigs to aid fabrication.</li>
<li>Responsible for conventional and CNC machining, to include managing direct labor to accomplish coverage on equipment in support of production needs.</li>
<li>Train and assist production members in the operation of conventional and CNC machining equipment in line with formal build plans.</li>
<li>Perform other job duties as assigned by the Plant Manager.</li>
</ul>
Qualifications 
<ul>
<li>Associate’s degree (A. A.) or equivalent from two-year college or technical school and/or experience in detailing and fabrication.</li>
<li>Must be able to use logic and reasoning to identify the strengths and weaknesses of alternative solutions, conclusions or approaches to production or productivity problems.</li>
<li>Experience with AutoCAD, Tekla, FeatureCam, Polyworks, Station Total, Laser Tracker Faro, and other software preferred.</li>
<li>Ability to communicate information and ideas in speaking, so others will understand.</li>
<li>Analyze information and evaluate results to choose the best solution and solve problems.</li>
<li>Must be able to schedule events, programs, and activities, as well as the work of others.</li>
<li>Job requires a willingness to lead, take charge, and offer opinions and direction.</li>
</ul>
 Additional Information 
Work Environment General office and production environment. Daily exposure to computer display and shop environment.&nbsp;&nbsp;
Remuneration We offer a competitive compensation and benefits package, as well as excellent opportunities for training and advancement.
Canam&nbsp;is an Equal Opportunity/Affirmative Action employer.&nbsp;All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.
If you need a reasonable accommodation for any part of the employment process, please contact us by email at <a href="mailto:lorri.boynton@canamgroupinc.com" target="_blank">lorri.boynton@canamgroupinc.com</a> and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this e-mail address.

Metrology Technician

<h3>Job Description</h3>
Job DescriptionCompany Description 
Are you ready to take the next step in your career and join a company that truly values your contributions? At Eurofins PSS, we offer more than just a job—we provide a rewarding, enriching, and fulfilling career path with opportunities for growth and advancement.
As part of our team, you’ll work in state-of-the-art laboratories alongside passionate professionals dedicated to the testing, development, and advancement of life-saving drug products. Together, we’re making the world a healthier and happier place to live.
Eurofins PSS is a global leader in life sciences, delivering a unique range of analytical testing services that help ensure the safety, authenticity, and accuracy of products and their ingredients. We partner with some of the world’s largest companies to make life and our environment safer, healthier, and more sustainable.
Our people are our chemistry—and we’re looking for talented individuals like you to join us in making a difference.
Job Description 
Advance your scientific career in&nbsp;Indianapolis, a thriving center for pharmaceutical and biotech innovation. We’re seeking a&nbsp;Metrologist Group Leader&nbsp;to oversee equipment maintenance, qualification, and team development in a GMP-regulated lab environment. This is a full-time leadership role with&nbsp;relocation assistance provided&nbsp;to support your move.
&nbsp;Why Relocate to Indianapolis?
<ul>
<li>Affordable cost of living with vibrant urban and suburban options</li>
<li>Expanding life sciences and pharmaceutical ecosystem</li>
<li>Relocation support and onboarding assistance to help you settle in smoothly</li>
</ul>
&nbsp;What You’ll Do
<ul>
<li>Lead equipment maintenance and qualification activities across lab operations</li>
<li>Troubleshoot technical issues and serve as a subject matter expert on lab instrumentation</li>
<li>Collaborate cross-functionally with internal teams, vendors, and global quality groups</li>
<li>Recommend and implement process improvements to enhance lab efficiency</li>
<li>Supervise and mentor team members, manage workflow, and conduct performance reviews</li>
<li>Ensure compliance with GMP standards and maintain accurate documentation</li>
</ul>
Qualifications 
<ul>
<li>Bachelor’s degree in physical sciences (e.g., chemistry, physics)</li>
<li>4+ years of&nbsp;industry lab experience, including leadership responsibilities</li>
<li>Strong troubleshooting skills and familiarity with CMMS systems</li>
<li>Excellent communication, organizational, and team leadership abilities</li>
<li>Authorization to work in the U.S. indefinitely without sponsorship</li>
<li>Willingness to relocate to Indianapolis –&nbsp;relocation support is available</li>
</ul>
 Additional Information 
<ul>
<li>Position is full-time, 8:00 am- 5:00 pm Overtime as needed.&nbsp;</li>
<li>Position is located in downtown Indianapolis, IN.&nbsp;</li>
<li>Excellent full-time benefits including comprehensive medical coverage, dental, and vision options</li>
<li>Life and disability insurance</li>
<li>401(k) with company match</li>
<li>Paid vacation and holidays</li>
<li>#LI-EB1</li>
</ul>
Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

Metrologist Group Leader - Relocation Opportunity to Indianapolis

<h3>Job Description</h3>
Job Description
MERL is looking for a highly motivated intern to work on an original research project in reconstruction/rendering dynamic 3D scenes. A strong background in 3D computer vision and/or computer graphics is required. Experience in the latest advances of deep learning in this area, such as neural radiance fields (NeRFs)/Gaussian Splatting (GS)/Point Map reconstruction methods, is an added plus and will be valued. The successful candidate is expected to have published at least one paper in a top-tier computer vision/graphics or machine learning venue, such as CVPR, ECCV, ICCV, SIGGRAPH, 3DV, ICML, ICLR, NeurIPS or AAAI, and possess solid programming skills in Python and popular deep learning frameworks like Pytorch. The goal would be for such a candidate to collaborate with MERL researchers to develop algorithms and prepare manuscripts for scientific publications. The position is available for graduate students on a Ph.D. track or those that have recently graduated with a Ph.D. Duration and start dates are flexible but are expected to last for at least 3 months. This internship is preferred to be onsite at MERL’s office in Cambridge, MA.
Required Specific Experience 
<ul>
<li>Prior publications in top computer vision/graphics and/or machine learning venues, such as CVPR, ECCV, ICCV, SIGGRAPH, 3DV, ICML, ICLR, NeurIPS or AAAI.</li>
<li>Experience in the latest novel-view synthesis approaches such as Neural Radiance Fields (NeRFs) or Gaussian Splatting (GS) and/or in the latest 3D point map reconstruction methods.</li>
<li>Proficiency in coding (particularly scripting languages like Python) and familiarity with deep learning frameworks, such as PyTorch or Tensorflow.</li>
</ul>
The pay range for this internship position will be $6-8K per month.
Mitsubishi Electric Research Labs, Inc. "MERL" provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, MERL complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.
MERL expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of MERL’s employees to perform their job duties may result in discipline up to and including discharge.
Working at MERL requires full authorization to work in the U.S and access to technology, software and other information that is subject to governmental access control restrictions, due to export controls. Employment is conditioned on continued full authorization to work in the U.S and the availability of government authorization for the release of these items, which might include without limitation, obtaining an export license or other documentation. MERL may delay commencement of employment, rescind an offer of employment, terminate employment, and/or modify job responsibilities, compensation, benefits, and/or access to MERL facilities and information systems, as MERL deems appropriate, to ensure practical compliance with applicable employment law and government access control restrictions. 
In addition to base pay, interns receive a relocation stipend, covered travel to and from MERL, and a monthly Charlie Card for local commuting. Interns are invited to participate in weekly social gatherings and professional development opportunities, including research talks by both internal and external speakers. Interns who meet the 90-day waiting period are also eligible for health insurance coverage. MERL provides immigration support for qualified candidates as needed. Employment is considered “at-will,” and the Company reserves the right to modify base salary or any other compensation program at any time, including for reasons related to individual performance, departmental or Company performance, and market conditions.

Internship - Reconstruction/Novel View Synthesis of Dynamic Scenes

<h3>Job Description</h3>
Job Description
WHDH-TV in Boston, MA is looking for an accurate weather forecaster for our newscasts. Must be able to generate creative, animated weather graphics. Must have an AMS Seal and a minimum of 3-5 years experience. WHDH-TV is an Equal Opportunity Employer. This position requires candidate to work 100% in Boston office.

Meteorologist - Weekend Mornings-FT

<h3>Job Description</h3>
Job DescriptionSalary: $160,000 - $180,000 
About Acrivon Therapeutics
 Acrivon is a clinical stage biopharmaceutical company discovering and developing precision medicines utilizing its proprietary Generative Phosphoproteomics AP3 platform. The platform allows the company to interpret and quantify compound specific, drug-regulated pathway activity levels inside the intact cell in an unbiased manner, yielding terabytes of proprietary data and delivering rapid, actionable insights. The Generative Phosphoproteomics AP3 platform is comprised of a growing suite of powerful, internally-developed tools, including the AP3 Data Portal, converting multimodal data into structured data for generative AI analyses, the AP3 KaiSR Kinase Substrate Relationship Predictor, and the AP3 Interactome. These distinctive capabilities enable the company to go beyond the limitations of traditional drug discovery, as well as current AI-based target-centric drug discovery, and rapidly design highly differentiated compounds with desirable pathway effects through intracellular protein network analyses and advance these agents into the clinic for streamlined development.
 
Acrivon is currently advancing its lead program, ACR-368 (also known as prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2b trial for endometrial cancer. The company has received Fast Track designation from the Food and Drug Administration, or FDA, for the investigation of ACR-368 as a monotherapy based on OncoSignature-predicted sensitivity in patients with endometrial cancer. The FDA has granted a Breakthrough Device designation for the ACR-368 OncoSignature assay for the identification of patients with endometrial cancer who may benefit from ACR-368 treatment. In addition, the company has initiated a third arm to the Phase 2b study without the need for a pre-treatment biopsy to evaluate ACR-368 with ultra-low-dose gemcitabine (ULDG) sensitization in all-comer, biomarker-unselected 2nd line patients with endometrial cancer who have all received prior treatment with chemotherapy and anti-PD-1.
 
Acrivon is also leveraging its proprietary Generative Phosphoproteomics AP3 platform for developing its co-crystallography-driven, internally discovered pipeline programs. These include ACR-2316, the companys second clinical stage asset, a novel, potent, selective WEE1/PKMYT1 inhibitor designed for superior single-agent activity through strong activation of not only CDK1 and CDK2, but also of PLK1 to drive pro-apoptotic cell death, as observed in preclinical studies against benchmark inhibitors. The Phase 1 trial of ACR-2316 is advancing with enrollment in the first three dose-escalation cohorts completed. Drug target engagement was observed at DL1 and 2 using the companys clinical mass spectrometry-based AP3 profiling, with evidence of approximate dose proportionality based on plasma pharmacokinetic analyses, and initial clinical activity and confirmed partial response. In addition, the company is advancing a preclinical program directed against an undisclosed cell cycle regulatory target.
Position Overview:
This position will apply technical expertise to support biomarker assaysprimarily digital imaging, analysis and associated workflows, data analysis, scripting and LIMSwithin our CLIA/CAP framework, and work closely with our biomarker platform team to advance our precision medicines in oncology.
Location:
This position will report to the CLIA Laboratory Director and be based at least 60% in our Watertown, MA facility, with no more than 40% in a home office.
Duties and Responsibilities:
<ul>
<li>Execute validated slide scanning and quantitative image analysis protocols for highcomplexity tests, including IHC and multiplex immunofluorescence assays.</li>
<li>Develop and execute validation plans for equipment and assay procedures including software and electronic workflow.</li>
<li>Collaborate with cross-functional teams to develop image analysis algorithms, scripts and workflows to support clinical and research assay development.</li>
<li>Lead all LIMS efforts including configurations, validations, document support and training.</li>
<li>Provide technical guidance on laboratory automation, data tracking and workflow optimization.</li>
<li>Assist with biostatistics for validation protocols and result analysis.</li>
<li>Collaborate with Quality, Regulatory, and IT teams to maintain a compliant, efficient laboratory.</li>
<li>Participate in proficiency testing and regulatory compliance.</li>
<li>Adhere to the laboratory's quality control policies, document all quality control activities, instrument and procedural calibrations and maintenance performed.</li>
<li>Follow the laboratory's established policies and procedures whenever test systems are not within the laboratory's established acceptable levels of performance.</li>
<li>Be capable of identifying problems that may adversely affect test performance or reporting of test results and either must correct the problems or immediately notify the general supervisor, technical supervisor, or Laboratory Director.</li>
<li>Document all corrective actions taken when test systems deviate from the laboratory's established performance specifications.</li>
<li>Work on special projects as assigned by management.</li>
</ul>
Required Skills/Abilities:
<ul>
<li>Minimum of masters degree in computer science, medical technology, histology, biology, or related field.</li>
<li>Minimum of 5 years of experience in clinical or research pathology laboratory.</li>
<li>Expertise in digital pathology platforms including multispectral imaging systems.</li>
<li>Familiarity with histology and IHC (including both bright field and fluorescence techniques).</li>
<li>Proficiency in Python, RStudio, HTML and laboratory information systems.</li>
<li>Familiarity with machine learning/AI applications</li>
<li>Detailoriented, precise, and adept at working in regulated environments.</li>
<li>Excellent communication, problem-solving, and leadership skills.</li>
<li>Ability to participate constructively on cross-functional and diverse teams.</li>
<li>Visual acuity for microscopic examination and computer use.</li>
</ul>
Acrivon Therapeutics is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation, or genetics. In addition to federal law requirements, Acrivon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment.

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